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The concept behind Azedra is to use MIBG to deliver the radioactive I131 at higher concentrations in the adrenal glands where pheochromocytoma or paraganglioma tumors originate relative to other tissues in the body.Since Azedra achieves a high 1:1 binding of Iodine 131 with Iobenguane (much higher than typical 1:2000), the rationale is that Azedra should be able to deliver higher concentrations directly to the tumor with lower radioactive Iodine 131 exposure in other tissues thereby improving efficacy and/or reducing side effects. This higher binding is achieved using a novel resin exchange manufacturing process that is similar to that used to manufacture (purify) proteins for therapeutic applications.What has been observed to date As first noted initially in the article Progenics: A Rose With One Thorn, there are some noticeable differences in the trial results between those generated and reported by Molecular Insight and those from Progenics. Key differences relate to both the number of doses received as well as the efficacy against the primary endpoint (number of patients with 50% reduction in antihypertensives for at least 6 months) and secondary endpoint (number of partial responses or PR).Comparison Of Azedra Primary And Secondary Endpoints By Trial SponsorSources: Aug 31 Progenics Press Release; Pryma et al 2014 NCCN Poster.In general, comparing the 41 patients who were treated under the Molecular Insight to the 27 patients under the Progenics portion of the trial there are the following notable differences:Number of Doses:82.9% of Molecular Insight patients received two doses vs.

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