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States only. In July 2017, new guidance was released for providers caring for pregnant women with possible Zika virus exposure to reflect the lower positive predictive value of diagnostic testing in the setting of decreasing prevalence of disease and the difficulty in determining the timing of infection based on serologic testing as the outbreak continued (2). All pregnant women should be asked about possible Zika virus exposure before and during the pregnancy at every prenatal care visit to guide appropriate diagnostic testing and clinical care.

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